Fig 17: ENSOTROL TECHNOLOGY 2) Portab System (Andrx Pharmaceuticals) :- PORTAB has an osmotic core, typically containing a water-soluble drug. The core includes a water-soluble component and a continuous polymer coating. The purpose of the soluble agent is to expand the core and thereby create microporous channels through which the drug is released. 3) Zeros tablet technology (ADD Drug Delivery Technologies AG, Switzerland):- The technology is used for lipophilic drug. It comprises of drug, excipients, gel forming agents. When fluid imbibes gel formation occurs with certain viscosity drug suspension is formed pushed out through the orifice. Tegretol XR(Carbamezapine), a successful product on the US market, is based on this technology as well. The contents of Tegretol-XR tablets are released through the small opening on one side. Fluid is absorbed through the shell, causing the contents to expand and slowly push out through the opening. 4) The Port System (Therapeutic system research laboratory Ann Arbor, MI, USA):- This capsule has three parts an active drug with osmotic agents, a slid able partition and a immediate release drug These all are encased by a semi-permeable membrane. At the fluid entry drug with an osmotic agents gets expanded creating osmotic pressure directly push the slider made of non-swellable polymer plug causing immediate release of drug after a lag time. This is suitable for continuous delivery of drug.Example-methylphenidate for the treatment of attention deficit hyperactivity disorder in school age children. Fig 18: The Port System 5) DURIN technology [10]:- DURIN technology use biodegradable polyester like lactide glycolide co-polymer as an excipient mixed with the drug for implantable drug formulation .It can load upto 70-80% of drug. Wide variety of drugs including hydrophobic, hydrophilic drug can be used. These esters get degraded by hydrolysis after drug release and are fully absorbed by tissues. The drug and excipients are mixed formed into rods, fiber, tablet, For example, Zoladex- goserelin used for prostrate cancer have been successfully developed implants in which the membrane includes a pore forming agent that will leach out upon exposure to an aqueous environment, creating a micro porous membrane The DURIN technology has successfully achieved controlled, zero-order drug release for up to 6 months in vivo.
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